|They are located on the chromosomes.||Chromosomes are the packed structure of a DNA with proteins.|
|Genes are composed of either DNA or RNA||Chromosomes composed of DNA, RNA and histones.|
|According to Human genome project, there are 30,000 genes in the human cell.||In Human cell there are 23 pair of chromosomes. In Gametic cell there are 23 chromosomes.|
|Gene mutation takes place at smaller scale.||Chromosome mutation takes place at larger scale. In evolution it takes time.
|Genetic mutation is not lethal. In fact is desirable at lower level of life.||Chromosome mutation is generally lethal.|
|Gene is not visible under microscope.||Chromosome is visible under microscope.|